2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

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Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. 상품명 효과 Purity Chemical Structure
  • HY-164703
    Lumateperone metabolite 1
    		98.26%
    Lumateperone metabolite 1 (Formula T) is a metabolite of Lumateperone (HY-17637). Lumateperone (ITI-007) is an orally active 5-HT2A receptor antagonist (Ki = 0.54 nM), a partial agonist of presynaptic D2 receptors and an antagonist of postsynaptic D2 receptors (Ki = 32 nM), and a dopamine D1 receptor modulator
    Lumateperone metabolite 1
  • HY-101723
    Modecainide
    		98.95%
    Modecainide is a major metabolite of Encainide, which is an antiarrhythmic agent.
    Modecainide
  • HY-171128
    PTX-M
    		99.95%
    PTX-M is an oxidized metabolite of Pentoxifylline (HY-B0715). Pentoxifylline is a phosphodiesterase inhibitor that can be used for the study of peripheral vascular, inflammatory, and immune diseases.
    PTX-M
  • HY-W069721
    N-Acetylsulfanilamide
    		99.86%
    N-Acetylsulfanilamide is a compound with potential anti-infective activity.
    N-Acetylsulfanilamide
  • HY-186080
    Melatonin-OH
    		98.72%
    Melatonin-OH is an oxidative Melatonin (HY-B0075) metabolite with free radical-scavenging activity. Melatonin-OH forms via Melatonin’s reaction with hydroxyl radicals (·OH). Melatonin-OH forms via Melatonin’s reaction with peroxynitrous acid or its activated form ONOOH.
    Melatonin-OH
  • HY-W008216S
    HMMNI-d3
    		99.90%
    HMMNI-d3 (Hydroxy Dimetridazole-d3) is deuterium labeled HMMNI (HY-W008216). HMMNI (Hydroxy dimetridazole) is a hydroxy metabolite of Dimetridazol (HY-B1244). Dimetridazole is a nitroimidazole class agent that combats protozoan infections.
    HMMNI-d<sub>3</sub>
  • HY-W1002768
    Cholic acid 3-sulfate sodium
    		99.36%
    Cholic acid 3-sulfate sodium is a metabolite of the primary bile acid Cholic acid (HY-N0324).
    Cholic acid 3-sulfate sodium
  • HY-137959
    Telmisartan acyl-β-D-glucuronide
    Telmisartan acyl-β-D-glucuronide is an acyl-β-D-glucuronide and a metabolite of Telmisartan (HY-13955). Telmisartan acyl-β-D-glucuronide can be converted back to Telmisartan upon incubation with Glucuronidase. Partial acyl migration of Telmisartan acyl-β-D-glucuronide occurs under physiological conditions.
    Telmisartan acyl-β-D-glucuronide
  • HY-W014225R
    3-Phenoxybenzoic acid (Standard)
    3-Phenoxybenzoic acid (Standard) is the analytical standard of 3-Phenoxybenzoic acid. This product is intended for research and analytical applications. 3-Phenoxybenzoic acid is the metabolite of pyrethroid insecticides. 3-Phenoxybenzoic acid induces immunotoxicity and oxidative stress, and inhibits the phagocytic ability of macrophages.
    3-Phenoxybenzoic acid (Standard)
  • HY-121609A
    Pholedrine hydrochloride
    		99.63%
    Pholedrine hydrochloride, the main metabolite of methamphetamine, is an indirectly acting sympathomimetic amine. Pholedrine hydrochloride is a cardiovascular agent exerting hypertensive and adrenergic effects. Pholedrine hydrochloride can produce mydriatic response and allow localization of the site of the interruption in the oculosympathetic pathway. Pholedrine hydrochloride can be used as a topical eye drop and a diagnostic agent for use in Horner's syndrome.
    Pholedrine hydrochloride
  • HY-148053
    Rezivertinib analogue 1
    		99.00%
    Rezivertinib analogue 1 is a process impurity of osimertinib mesylate. Rezivertinib analogue 1 can be used in the study of non-small cell lung cancer.
    Rezivertinib analogue 1
  • HY-12388AS
    N-Desmethyl clomipramine-d3 hydrochloride
    		99.81%
    N-Desmethyl Clomipramine-d3 (hydrochloride) is the deuterium labeled N-Desmethyl Clomipramine. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine
    N-Desmethyl clomipramine-d<sub>3</sub> hydrochloride
  • HY-N7177
    Hydroxytanshinone IIA
    		99.83%
    Hydroxytanshinone IIA is a hydroxylated metabolite of Tanshinone IIA. Tanshinone IIA may suppress angiogenesis by targeting the protein kinase domains of VEGF/VEGFR2.
    Hydroxytanshinone IIA
  • HY-128379
    Labetalone hydrochloride
    		99.27%
    Labetalone hydrochloride is an impurity of Labetalol. Labetalol is an orally active adrenoceptor blocking agent which is a competitive antagonist at both alpha- and beta-adrenoceptor sites.
    Labetalone hydrochloride
  • HY-117229
    Sonidegib metabolite M48
    		98.0%
    Sonidegib metabolite M48 is the main circulating metabolite of Sonidegib. Sonidegib is a hedgehog pathway inhibitor. M48 showed a much longer Tmax (60 h) than Sonidegib.
    Sonidegib metabolite M48
  • HY-143840S
    2-Hydroxy Atorvastatin-d5 disodium
    2-Hydroxy Atorvastatin-d5 disodium is the deuterium labeled 2-Hydroxy Atorvastatin disodium. 2-Hydroxy atorvastatin calcium salt is a hydroxy metabolite of Atorvastatin calcium salt. Atorvastatin is a potent HMG-CoA reductase inhibitor with an IC50 value of 8 nM.
    2-Hydroxy Atorvastatin-d<sub>5</sub> disodium
  • HY-43670
    Chlorthalidone impurity
    		99.68%
    Chlorthalidone impurity is a metabolite of Chlorthalidone (HY-15833). Chlorthalidone is a thiazide-like diuretic used to treat hypertension.
    Chlorthalidone impurity
  • HY-W009512
    CVT-2738
    		99.81%
    CVT-2738 is an orally active metabolite of Ranolazine (HY-B0280). CVT-2738 has a protective effect against Isoprenaline (HY-108353)-induced myocardial ischemia in mice. CVT-2738 can be used in myocardial ischemia research.
    CVT-2738
  • HY-124542
    5-Hydroxydiclofenac
    		99.52%
    5-Hydroxydiclofenac is a major metabolite of Diclofenac (HY-15036). 5-Hydroxydiclofenac is formed by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C189, CYP2C19, and CYP2C8. 5-Hydroxydiclofenac shows apoptotic effects in hepatocytes.
    5-Hydroxydiclofenac
  • HY-W576312
    N,N-Dimethyltryptamine N-oxide
    		99.8%
    N,N-Dimethyltryptamine N-oxide is a metabolite of N,N-Dimethyltryptamine.
    N,N-Dimethyltryptamine N-oxide
Cat. No. 상품명 / Synonyms Application Reactivity